Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia.

@article{Liao1995PolymorphicTM,
  title={Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia.},
  author={Ping Liao and Mary V. Relling and Qing Liu and C. H. Pui and William E. Evans},
  journal={Blood},
  year={1995},
  volume={85 7},
  pages={1897-902}
}
The activity of thiopurine methyltransferase (TPMT) exhibits genetic polymorphism, with approximately 1 in 300 individuals inheriting TPMT deficiency as an autosomal recessive trait, and about 11% having intermediate activity (ie, heterozygotes). Patients with TPMT deficiency accumulate excessive concentrations of 6-thioguanine nucleotides (TGNs) and develop severe toxicity when treated with standard dosages of mercaptopurine. High TPMT activity has been associated with lower concentrations of… CONTINUE READING
57 Citations
23 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Lambooy LHJ, Trijbels FJM: The importance of methylthio-IMP for methymercaptopurine ribonucleoside cytotoxicity in Molt F4 human malignant T-lymphoblasts

  • MHJ Vogt, EH Stet, RA de Abreu, JPM Bokkerink
  • Biochim Biophys Acta 1181:189,
  • 1993

The importance of methylthio - IMP for methy - mercaptopurine ribonucleoside cytotoxicity in Molt F 4 human malignant T - lymphoblasts

  • Vogt MHJ, EH Stet, RA deAbreu, Bokkerink JPM, Lambooy LHJ, Trijbels FJM
  • Biochim Biophys Acta
  • 1993

Similar Papers

Loading similar papers…