Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF- beta production

@article{Messer1991PolymorphicSO,
  title={Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF- beta production},
  author={Gerald Messer and Ulrich Spengler and M C Jung and G. Honold and K. Bloemer and Gerd Rudolf Pape and Gert Riethmueller and Elisabeth H. Weiss},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={173},
  pages={209 - 219}
}
Since a dysregulated synthesis of tumor necrosis factor alpha (TNF-alpha) may be involved in the pathogenesis of autoimmune diseases, it was of interest to precisely locate the recently reported NcoI restriction fragment length polymorphism (RFLP) of the TNF-alpha region. However, by mapping of 56.8 kb of overlapping cosmid clones and direct sequencing, we… CONTINUE READING