Polymorphic sites and the mechanism of evolution in human mitochondrial DNA.

@article{Cann1984PolymorphicSA,
  title={Polymorphic sites and the mechanism of evolution in human mitochondrial DNA.},
  author={Rebecca Louise Cann and W. M. Brown and A. C. Wilson},
  journal={Genetics},
  year={1984},
  volume={106 3},
  pages={479-99}
}
Twelve restriction enzymes were used to screen for the presence or absence of cleavage sites at 441 locations in the mitochondrial DNA of 112 humans from four continents. Cleavage maps were constructed by comparison of DNA fragment sizes with those expected from the published sequence for one human mtDNA. One hundred and sixty-three of the sites were polymorphic, i.e., present in some individuals but absent from others, 278 sites being invariant. These polymorphisms probably result from single… CONTINUE READING

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