Polymorphic metabolism of beta-adrenoceptor antagonists.

@article{Silas1984PolymorphicMO,
  title={Polymorphic metabolism of beta-adrenoceptor antagonists.},
  author={J. H. Silas and Martin S. Lennard and Geoffrey T Tucker and Lawrence E. Ramsay and H. F. Woods},
  journal={British journal of clinical pharmacology},
  year={1984},
  volume={17 Suppl 1},
  pages={
          11S-19S
        }
}
  • J. Silas, M. Lennard, H. Woods
  • Published 1 February 1984
  • Biology, Chemistry, Medicine
  • British journal of clinical pharmacology
Most beta-adrenoceptor blockers undergo extensive oxidative metabolism. The evidence for polymorphism of the debrisoquine type is reviewed. The AUC and half-life of metoprolol were considerably greater in poor metabolisers (PM) of debrisoquine than in extensive metabolisers (EM). Metoprolol alpha-hydroxylation is impaired and O-dealkylation must also be affected. Polymorphism in the former route has been demonstrated in a population of 143 patients to be directly related to debrisoquine… 
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