Polymorphic hydroxylation of Debrisoquine in man.

@article{Mahgoub1977PolymorphicHO,
  title={Polymorphic hydroxylation of Debrisoquine in man.},
  author={A A Mahgoub and Jeffrey R Idle and L. G. Dring and Richard Lancaster and Robert L. Smith},
  journal={Lancet},
  year={1977},
  volume={2 8038},
  pages={584-6}
}
Debrisoquine and its primary metabolite, 4-hydroxydebrisoquine, were measured in the urine of 94 volunteers after a single oral dose of 10 mg debrisoquine. The ratio between excreted debrisoquine and its metabolite was bimorphically distributed in the study population. Family studies supported the view that alicyclic 4-hydroxylation of debrisoquine is controlled by a single autosomal gene and that a defect in this metabolic step is caused by a recessive allele.