Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis.

@article{Crawley1999PolymorphicHO,
  title={Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis.},
  author={Edward F. Crawley and R Kay and Julie Sillibourne and Pravin Patel and Ian Hutchinson and Pat Woo},
  journal={Arthritis and rheumatism},
  year={1999},
  volume={42 6},
  pages={
          1101-8
        }
}
  • Edward F. Crawley, R Kay, +3 authors Pat Woo
  • Published in Arthritis and rheumatism 1999
  • Medicine, Biology
  • OBJECTIVE To determine the distribution of the interleukin-10 (IL-10) 5' flanking region haplotypes in children with arthritis and in controls, and to investigate the functional significance of each haplotype. METHODS Sequence-specific oligonucleotide probing was used to determine haplotype frequency. Transient transfection studies were used to investigate the transcription of reporter genes driven by each haplotype. Whole blood cultures were performed to assess IL-10 production by each… CONTINUE READING

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