Polymorphic eruption of pregnancy: Review of literature

  title={Polymorphic eruption of pregnancy: Review of literature},
  author={Pedro Brand{\~a}o and B{\'a}rbara Sousa-Faria and Carla Marinho and Pedro Vieira-Enes and Anabela Melo and Lurdes Mota},
  journal={Journal of Obstetrics and Gynaecology},
  pages={137 - 140}
Abstract Polymorphic Eruption of Pregnancy (PEP) is one of the most common dermatosis related to pregnancy. PEP usually consists of pruritic papules and plaques appearing in the third trimester of pregnancy. It is more common in primigravidae and twin pregnancies. Although not associated with poorer foetal or maternal outcomes, it may be hard for pregnant women to endure. The diagnosis is easy if suspected, though sometimes it may be hard to distinguish from other dermatosis such as atopic… 


This report describes an unusual patient with singleton pregnancy presenting at 41 weeks gestation with sudden onset intense itching and rash on abdomen, upper part of legs and arms.

Post-partum Polymorphic Eruption of Pregnancy

The patient had an acute broad highly pruritic rash with coalescent papules and plaques affecting the abdominal wall, proximal arms and tights and one week after topical steroid treatment the patient had evident recovery both in pruritus and cutaneous lesions.

Postpartum polymorphic eruption of pregnancy: an unusual presentation

A case of postpartum PEP occurring in each of the patient’s three pregnancies is presented.

[Polymorphic eruption of pregnancy, a differential diagnosis of severe reactions to medications].

An allergy assessment is recommended as part of the optimal multidisciplinary management of each patient in order to identify the substance that is involved as the cause of the disease and, therefore, to avoid unnecessary restrictions.

Diagnostic Pitfall in Atypical Febrile Presentation in a Patient with a Pregnancy-Specific Dermatosis—Case Report and Literature Review

A case of a 36-year-old patient with a 32-week pregnancy who was admitted with a generalized pruritic rash accompanied by fever and gave birth by cesarean section to a healthy newborn without dermatological lesions or other conditions is presented.

Autoimmune bullous diseases during pregnancy: insight into pathogenetic mechanisms and clinical features.

An updated overview on the pathophysiologic mechanisms of pregnancy-associated or pregnancy-exacerbated AIBDs is provided, focusing also on peculiar clinical features of these disorders.

Connective tissue and dermatological disorders in pregnancy

Jeukende huidafwijkingen in de zwangerschap

De meeste huidaandoeningen die leiden tot jeuk tijdens de zwangerschap zijn onschuldig, maar cholestase en pemphigoid gestationis brengen risico’s met zich mee. Bij cholestase is er jeuk zonder

The Sonographic Evaluation of Gestational Age: A Comparative Study Utilizing Different Biometric Measurement Indices and Fetal Kidney Length

It can be assumed that FKL might be a suitable index for determining gestational age especially in the late second and third trimester, when other measurement indices are less accurate.

Recognizing, Diagnosing, and Managing Pregnancy Dermatoses

A comprehensive literature review of pregnancy dermatoses focusing on nomenclature, epidemiology, pathogenesis, clinical presentation, diagnosis, differential diagnosis, maternal risk, fetal risk, and treatment is provided.



Pruritic urticarial papules and plaques of pregnancy: polymorphic eruption of pregnancy (PUPPP).

Polymorphic eruption of pregnancy

Polymorphic eruption of pregnancy (PEP) is a benign, self‐limiting, pruritic disorder of pregnancy, which usually affects the primigravida during the last trimester or immediately postpartum. Its

Polymorphic eruption of pregnancy with palmoplantar involvement that developed after delivery

A case of polymorphic eruption of pregnancy associated with palmoplantar involvement that developed in the postpartum period is reported.

Polymorphic eruption of pregnancy in a photodistribution: a potentially new association?

A retrospective analysis of 181 patients with PEP in a large mixed ethnic population found that 13% of patients had multiple gestation pregnancies, with excessive maternal weight gain in 78%.

Pruritic urticarial papules and plaques of pregnancy: Current status

Histology is non‐specific, but consistently shows mild lymphohistiocytic perivascular inflammatory infiltrate with a variable number of eosinophils, and the maternal and fetal prognosis are generally unaffected.

Polymorphic Eruption of Pregnancy Presented with Targetoid Lesions: A Report of Two Cases

Targetoid lesions in PEP are an uncommon presentation, and the differential diagnosis of PEP along with other dermatoses should be considered, however, the prognosis for this type of P EP is not different from that for classic PEP.


The skin changes in pregnancy can be either physiological (hormonal), changes in pre-existing skin diseases or development of new pregnancy specific dermatoses, which are seen only in pregnancy.

A case-control study of polymorphic eruption of pregnancy.

Specific dermatoses of pregnancy and their treatment

The clinical characteristics, diagnosis and treatment of five dermatoses occurring during pregnancy are reviewed: pruritic urticarial papules and plaques ofregnancy, atopic eruption of pregnancy, pemphigoid gestationis, intrahepatic cholestasis of pregnancy and pustular psoriasis of pregnancy.

Polymorphic eruption of pregnancy developing in the puerperium

A patient with the clinical and histological features of polymorphic eruption of pregnancy, whose rash developed 4 weeks after delivery of a singleton pregnancy, is reported.