Polymorphic acetylation procainamide in man.

@article{Reidenberg1975PolymorphicAP,
  title={Polymorphic acetylation procainamide in man.},
  author={Marcus M. Reidenberg and Dr Dennis E. Drayer and Micha Levy and Harold Warner},
  journal={Clinical pharmacology and therapeutics},
  year={1975},
  volume={17 6},
  pages={722-30}
}
N-Acetylprocainamide (NAPA) and procainamide plasma and urine concentrations were determined by thin-layer chromatography (TLC) densitometry in people of known acetylator phenotype (dapsone phenotyping) taking procainamide for more than 3 days. The plasma NAPA/procainamide ratio 3 hr after the last dose for fast acetylators (mean plus or minus SD) is 1.8 plus or minus 0.59 (N equal to 8) and for slow acetylators, 0.61 plus or minus 0.09 (N equal to 6) P smaller than 0.001). The renal clearance… CONTINUE READING

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