Polymorphic acetylation of sulfamethazine in a Nigerian (Yoruba) population.

  title={Polymorphic acetylation of sulfamethazine in a Nigerian (Yoruba) population.},
  author={Loice H. Jeyakumar and M R French},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={11 5},
1. Sulfamehtazine was administered orally to 165 Yoruba subjects (40 mg/kg body wt.). Free and acetylated sulfamethazine were determined in the 6 h urines. 2. The population frequency histogram for percentage of urinary acetylated sulfamethazine was bimodal, although not completely resolved. Slow acetylators constituted 45% of the population studied. 3. This Yoruba population did not differ statistically (P greater than 0.05) in this respect from the two major tribally distinct groups in… CONTINUE READING

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