Polymorphic Variation in TIRAP Is Not Associated with Susceptibility to Childhood TB but May Determine Susceptibility to TBM in Some Ethnic Groups

@inproceedings{Dissanayeke2009PolymorphicVI,
  title={Polymorphic Variation in TIRAP Is Not Associated with Susceptibility to Childhood TB but May Determine Susceptibility to TBM in Some Ethnic Groups},
  author={Shobana Rebecca Dissanayeke and Samuel Levin and Sandra Pienaar and Kathryn Wood and Brian Eley and David Beatty and Howard Henderson and Suzanne M Anderson and Michael Levin},
  booktitle={PloS one},
  year={2009}
}
Host recognition of mycobacterial surface molecules occurs through toll like receptors (TLR) 2 and 6. The adaptor protein TIRAP mediates down stream signalling of TLR2 and 4, and polymorphisms in the TIRAP gene (TIRAP) have been associated with susceptibility and resistance to tuberculosis (TB) in adults. In order to investigate the role of polymorphic variation in TIRAP in childhood TB in South Africa, which has one of the highest TB incidence rates in the world, we screened the entire open… CONTINUE READING
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The immunogenetics of human infectious diseases

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Highly Influential
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