Polymorphic MHC class II promoters exhibit distinct expression pattern in various antigen-presenting cell lines.

@article{Janitz1997PolymorphicMC,
  title={Polymorphic MHC class II promoters exhibit distinct expression pattern in various antigen-presenting cell lines.},
  author={Michal Janitz and Avrion Mitchison and Luzie Reiners-Schramm and Roland Lauster},
  journal={Tissue antigens},
  year={1997},
  volume={49 2},
  pages={99-106}
}
The promoter regions of MHC class II genes are characterized by the presence of conserved sequence motifs called S,X and Y boxes, which are crucial for regulation of transcription of these genes. In humans, promoter polymorphism is known to result in differential transcriptional activity at both inter-locus and inter-allelic levels, but it is not yet known how this relates to tissue-specific expression of MHC class II molecules. We sequenced the 5' regulatory regions of alpha and beta genes of… CONTINUE READING

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