Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.

@article{Zanger2007PolymorphicCM,
  title={Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.},
  author={Ulrich M. Zanger and Kathrin E Klein and Tanja Saussele and Julia K Blievernicht and Marco Hans Hofmann and Matthias Schwab},
  journal={Pharmacogenomics},
  year={2007},
  volume={8 7},
  pages={
          743-59
        }
}
Polymorphisms in drug-metabolizing enzymes and drug transporters contribute to wide and inheritable variability in drug pharmacokinetics, response and toxicity. One of the less well-studied human cytochrome P450s is (CYP)2B6, a homologue of the rodent phenobarbital-inducible CYP2B enzymes. Clinically used drug substrates include cytostatics (cyclophosphamide), HIV drugs (efavirenz and nevirapine), antidepressants (bupropion), antimalarials (artemisinin), anesthetics (propofol) and synthetic… CONTINUE READING
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