Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population.

  title={Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population.},
  author={Sayeh Ezzikouri and Bouchra Kitab and Khadija Rebbani and Agn{\'e}s Marchio and Simon Wain-Hobson and Anne Dejean and J-P Vartanian and Pascal Pineau and Soumaya Benjelloun},
  journal={Journal of viral hepatitis},
  volume={20 10},
The cytidine deaminase apolipoprotein B mRNA editing catalytic subunit-3 (APOBEC3) induces G-to-A hypermutation in hepatitis B virus (HBV) genomes and operates as part of the innate antiviral immune system. We investigated the associations between the presence of APOBEC3 variants and HBV carriage in a case-control study in the Moroccan population. A polymorphic deletion affecting the APOBEC3B gene and the H186R variant of APOBEC3G were genotyped in 179 HBV chronic carriers and 216 healthy… CONTINUE READING
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