Polymodal activation of the endocannabinoid system in the extended amygdala

  title={Polymodal activation of the endocannabinoid system in the extended amygdala},
  author={Nagore Puente and Yihui Cui and Olivier Lassalle and Mathieu Lafourcade and François Georges and Laurent Venance and Pedro Grandes and Olivier J.J. Manzoni},
  journal={Nature Neuroscience},
The reason why neurons synthesize more than one endocannabinoid (eCB) and how this is involved in the regulation of synaptic plasticity in a single neuron is not known. We found that 2-arachidonoylglycerol (2-AG) and anandamide mediate different forms of plasticity in the extended amygdala of rats. Dendritic L-type Ca2+ channels and the subsequent release of 2-AG acting on presynaptic CB1 receptors triggered retrograde short-term depression. Long-term depression was mediated by postsynaptic… 
Drug-Induced Alterations of Endocannabinoid-Mediated Plasticity in Brain Reward Regions
Various forms of eCB-mediated synaptic plasticity present in regions of the brain involved in reward and reinforcement are reviewed and the potential physiological relevance of maladaptive eCB signaling to addiction vulnerability is explored.
Control of synaptic function by endocannabinoid-mediated retrograde signaling
  • M. Kano
  • Biology, Chemistry
    Proceedings of the Japan Academy. Series B, Physical and biological sciences
  • 2014
The mechanisms underlying endocannabinoid-mediated synaptic modulation are made an overview and it is demonstrated that the endoc cannabinoid system itself is plastic, which can be either up- or down-regulated by experimental or environmental conditions.
Endocannabinoid-Mediated Synaptic Plasticity
This review will briefly review the signaling of cannabinoid-1 (CB1) and cannabinoid-2 (CB2) receptors and then explore some of the roles endocannabinoids play in mediating diverse forms of synaptic plasticity, with an emphasis on recent findings.
Functional diversity on synaptic plasticity mediated by endocannabinoids
  • R. Cachope
  • Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2012
The aim of this review is to succinctly present the most common forms of eCB-mediated modulation of synaptic transmission, while also illustrating the multiplicity of effects resulting from specializations of this signalling system at the circuital level.
Endocannabinoid Signaling and Synaptic Function
Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System.
This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies on the role of eCBs in shaping neural circuit function to regulate behaviors.
Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release
The findings indicate that constitutive CB1 activity has pivotal function in the tonic control of hippocampal GABA release and indicate that the synaptic effects of tonic 2-AG release are tightly controlled by presynaptic MGL activity and also by postsynaptic endovanilloid signaling and FAAH activity.


Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
It is shown that stimulation of prelimbic cortex afferents at naturally occurring frequencies causes a long-term depression of nucleus accumbens glutamatergic synapses mediated by eCB release and presynaptic CB1 receptors.
Endocannabinoid-mediated control of synaptic transmission.
This review aims to integrate the current understanding of functions of the endocannabinoid system, especially focusing on the control of synaptic transmission in the brain, and summarizes recent electrophysiological studies carried out on synapses of various brain regions and discusses how synaptic transmission is regulated by endoc cannabinoidoid signaling.
Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses
It is shown, by using two independent riboprobes, that principal cell populations of the hippocampus express high levels of diacylglycerol lipase α (DGL-α), the enzyme involved in generation of the endocannabinoid 2-arachidonoyl- glycerol (2-AG), which may contribute to homosynaptic plasticity of excitatory synapses and to heterosynptic plasticity between excitatories and inhibitory contacts.
Endocannabinoid signaling and long-term synaptic plasticity.
The induction and expression of eCB-LTD, although remarkably similar at various synapses, are controlled by an array of regulatory influences that are just beginning to uncover, and this complexity endows eCBs with important computational properties, such as coincidence detection and input specificity, critical for higher CNS functions like learning and memory.
Stimulation of Endocannabinoid Formation in Brain Slice Cultures through Activation of Group I Metabotropic Glutamate Receptors
2-AG is a primary endocannabinoid mediator of mGlu receptor-dependent neuronal plasticity and realtime polymerase chain reaction and immunostaining analyses indicate that DGL-β is the predominant DGL isoform expressed in corticostriatal and hippocampal slices and that this enzyme is highly expressed in striatal neurons, where it is colocalized with PLC-β1.
Molecular Components and Functions of the Endocannabinoid System in Mouse Prefrontal Cortex
The data show that the endocannabinoid -retrograde signaling plays a prominent role in long-term synaptic plasticity at the excitatory synapses of the PFC.
Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens
It is found that synaptic activation of group I metabotropic glutamate receptors in NAc MSNs in the indirect, but not direct, pathway led to the production of endocannabinoids, which activated presynaptic CB1 receptors to trigger endoc cannabinoidoid-mediated long-term depression (eCB-LTD) and postsynaptic transient receptor potential vanilloid 1 (TRPV1) channels to trigger a form of LTD resulting from endocytosis of AMPA receptors.
TRPV1 activation by endogenous anandamide triggers postsynaptic LTD in dentate gyrus
It is found that TRPV1 suppressed excitatory transmission in rat and mouse dentate gyrus by regulating postsynaptic function in an input-specific manner, revealing a previously unknown form of endocannabinoid- and TRP V1-mediated regulation of synaptic strength at central synapses.
Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens
Electrophysiological techniques and immunohistochemistry suggest that CB1 receptors are located on the cortical afferents to the nucleus and can reduce glutamate synaptic transmission within the NAc by modulating K+ channels activity.