Polymodal activation of the endocannabinoid system in the extended amygdala

@article{Puente2011PolymodalAO,
  title={Polymodal activation of the endocannabinoid system in the extended amygdala},
  author={Nagore Puente and Yihui Cui and Olivier Lassalle and Mathieu Lafourcade and François Georges and Laurent Venance and Pedro Grandes and Olivier J.J. Manzoni},
  journal={Nature Neuroscience},
  year={2011},
  volume={14},
  pages={1542-1547}
}
The reason why neurons synthesize more than one endocannabinoid (eCB) and how this is involved in the regulation of synaptic plasticity in a single neuron is not known. We found that 2-arachidonoylglycerol (2-AG) and anandamide mediate different forms of plasticity in the extended amygdala of rats. Dendritic L-type Ca2+ channels and the subsequent release of 2-AG acting on presynaptic CB1 receptors triggered retrograde short-term depression. Long-term depression was mediated by postsynaptic… 
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