Polymodal activation of the endocannabinoid system in the extended amygdala

@article{Puente2011PolymodalAO,
  title={Polymodal activation of the endocannabinoid system in the extended amygdala},
  author={N. Puente and Yihui Cui and O. Lassalle and M. Lafourcade and F. Georges and L. Venance and P. Grandes and O. Manzoni},
  journal={Nature Neuroscience},
  year={2011},
  volume={14},
  pages={1542-1547}
}
  • N. Puente, Yihui Cui, +5 authors O. Manzoni
  • Published 2011
  • Biology, Medicine
  • Nature Neuroscience
  • The reason why neurons synthesize more than one endocannabinoid (eCB) and how this is involved in the regulation of synaptic plasticity in a single neuron is not known. We found that 2-arachidonoylglycerol (2-AG) and anandamide mediate different forms of plasticity in the extended amygdala of rats. Dendritic L-type Ca2+ channels and the subsequent release of 2-AG acting on presynaptic CB1 receptors triggered retrograde short-term depression. Long-term depression was mediated by postsynaptic… CONTINUE READING

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