Polymicrobial sepsis is associated with decreased hepatic oxidative phosphorylation and an altered metabolic profile.

@article{Whelan2014PolymicrobialSI,
  title={Polymicrobial sepsis is associated with decreased hepatic oxidative phosphorylation and an altered metabolic profile.},
  author={Sean P.J. Whelan and Evie H. Carchman and Benjamin C Kautza and Ibrahim Nassour and Kevin P. Mollen and Daniel Enrique Zamarr{\'o}n Escobar and Hernando Gomez and Matthew A Rosengart and Sruti S. Shiva and Brian S Zuckerbraun},
  journal={The Journal of surgical research},
  year={2014},
  volume={186 1},
  pages={297-303}
}
BACKGROUND Organ failure in sepsis accounts for significant mortality worldwide. Mitochondrial and metabolic responses are central to the overall response of the cell, and thus of the organ and organism. Adaptive responses in metabolism are critical to the recovery at the cellular level. The purpose of these investigations was to test the hypothesis that sepsis is associated with decreased aerobic respiration and significant metabolic changes in the liver. METHODS C57BL/6 mice underwent cecal… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Mitochondria and cellular oxygen sensing in the HIF pathway.

The Biochemical journal • 2008
View 7 Excerpts
Highly Influenced

Cellular oxygen utilization in health and sepsis

GI van Boxel, WL Doherty, M. Parmar
Contin Educ Anaesth Crit Care Pain 2012;12:207 • 2012
View 2 Excerpts

Cellular dysfunction in sepsis.

Clinics in chest medicine • 2008
View 1 Excerpt

Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure.

American journal of physiology. Regulatory, integrative and comparative physiology • 2004
View 2 Excerpts

Similar Papers

Loading similar papers…