Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production.

@article{Ayala1994PolymicrobialSB,
  title={Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production.},
  author={Alfred Ayala and Z{\"o}e K. Deol and Deborah L Lehman and C D Herdon and Irshad H. Chaudry},
  journal={The Journal of surgical research},
  year={1994},
  volume={56 6},
  pages={579-85}
}
Although studies indicate that polymicrobial sepsis produces marked depression in lymphocyte functions, it remains unclear whether this dysfunction is due to the chronic exposure of immune cells to endotoxin (ETX; a product of the gram-negative bacterial cell wall) at levels typically encountered in the septic state. The aim of this study, therefore, was to determine whether the changes in lymphokine release seen during polymicrobial sepsis are comparable to those observed with chronic ETX… CONTINUE READING
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