Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen.

@article{Cilurzo2005PolymethacrylatesAC,
  title={Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen.},
  author={Francesco Cilurzo and Paola Minghetti and Antonella Casiraghi and Leila Tosi and Stefania Pagani and Luisa Montanari},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2005},
  volume={60 1},
  pages={61-6}
}
The feasibility of a monolayer patch based on polydimethylsiloxane pressure sensitive adhesive containing ibuprofen (IB) in supersaturated condition was studied. The efficacy of three low molecular weight excipients (propylene glycol, PG, Cremophor EL and Cremophor RH) and of two copolymers of methacrylic acid (Eudragit((R)) E, EuE, and Eudragit((R)) RL, EuRL) as IB crystallization inhibitors was tested. The performances of the patches were evaluated in terms of drug release and human stratum… CONTINUE READING
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