Polymers for the sustained release of proteins and other macromolecules

@article{Langer1976PolymersFT,
  title={Polymers for the sustained release of proteins and other macromolecules},
  author={Robert Langer and Judah M Folkman},
  journal={Nature},
  year={1976},
  volume={263},
  pages={797-800}
}
SINCE the first demonstration that silicone rubber1 could be used as an implantable carrier for sustained delivery of low molecular weight compounds in animal tissues, various drug delivery systems have been developed. But except for the reports of Davis2,3 and Girnbrone et al.4, there has been little success in the development of slow release agents for large molecular weight compounds. Furthermore, the polymers used in those studies, polyvinylpyrrolidone and polyacrylamide, are often… CONTINUE READING
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