Polymers for gene delivery across length scales.

  title={Polymers for gene delivery across length scales.},
  author={David D Putnam},
  journal={Nature materials},
  volume={5 6},
A number of human diseases stem from defective genes. One approach to treating such diseases is to replace, or override, the defective genes with normal genes, an approach called 'gene therapy'. However, the introduction of correctly functioning DNA into cells is a non-trivial matter, and cells must be coaxed to internalize, and then use, the DNA in the desired manner. A number of polymer-based synthetic systems, or 'vectors', have been developed to entice cells to use exogenous DNA. These… CONTINUE READING