Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain.

@article{Ulbrich1980PolymersCE,
  title={Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain.},
  author={Karel Ulbrich and E I Zacharieva and B Obereigner and Jindřich Kope{\vc}ek},
  journal={Biomaterials},
  year={1980},
  volume={1 4},
  pages={199-204}
}
Copolymers of N-(2-hydroxypropyl)methacrylamide were prepared, in which synthetic polymer chains are joined by crosslinks containing oligopeptidic sequences degradable with papain, with the general structure P-(Gly)n-X-Y-NH-(CH2)6-NH-Y-X-(Gly)n-P (P is the polymer chain, n = 1,2; X...Phe, Val, Gly; Y...Lys, Gly, Tyr, Ala, Phe). The relationship between the structure of these polymeric substrates and their degradability with papain was investigated viscometrically. It was shown that -Phe-Lys… CONTINUE READING

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