Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat.

@article{Irwin2008PolymerizedBH,
  title={Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat.},
  author={David C Irwin and B. J. Foreman and Ken Morris and Molly White and Tim Sullivan and Robert A Jacobs and Eric Monnet and Tim Guinee Richard Hackett and Martha C. TissotvanPatot and Karyn L Hamilton and Robert W. Gotshall},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 3},
  pages={
          H1090-H1099
        }
}
Hemoglobin-based oxygen carriers (HBOC) have been primarily studied for blood loss treatment. More recently infusions of HBOC in euvolemic subjects have been proposed for a wide variety of potential therapies in which increased tissue oxygenation would be beneficial. However, compared with the exchange transfusion models to study blood loss, less is known about HBOC oxygen delivery and vasoacitvity when it is infused in euvolemic subjects. We hypothesized that HBOC [polymerized bovine… CONTINUE READING

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