Polymerization of murine recombinant prion protein in nucleic acid solution

@article{Nandi1999PolymerizationOM,
  title={Polymerization of murine recombinant prion protein in nucleic acid solution},
  author={Pradip K. Nandi and Estelle Leclerc},
  journal={Archives of Virology},
  year={1999},
  volume={144},
  pages={1751-1763}
}
Summary. Recombinant prion protein has been used earlier to understand the structural properties of cellular prion protein PrPC and to understand conformational change of PrPC to its isoform, PrPSc which is believed to be responsible for the prion disease. Here we report that murine recombinant prion protein, MoPrPC polymerizes in the presence of nucleic acid. The aggregation process and the properties of the aggregates have been monitored by physical, biochemical and ultrastructural studies… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

Murine recombinant prion protein induces ordered aggregation of linear nucleic acids to condensed globular structures

P. K. Nandi, P.-Y. Sizaret
  • Archives of Virology
  • 2001
VIEW 8 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Nucleic acid-mediated protein aggregation and assembly.

  • Advances in protein chemistry and structural biology
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Aptamers to explore prion protein interactions with nucleic acids.

  • Frontiers in bioscience
  • 2010
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Nucleic acid induced protein aggregation and its role in biology and pathology.

  • Frontiers in bioscience
  • 2009
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A Sequence-Dependent DNA Condensation Induced by Prion Protein

  • Journal of nucleic acids
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.