Polymerization of calsequestrin. Implications for Ca2+ regulation.

  title={Polymerization of calsequestrin. Implications for Ca2+ regulation.},
  author={HaJeung Park and Si Wu and A. Keith Dunker and ChulHee Kang},
  journal={The Journal of biological chemistry},
  volume={278 18},
Two distinct dimerization contacts in calsequestrin crystals suggested a mechanism for Ca(2+) regulation resulting from the occurrence of coupled Ca(2+) binding and protein polymerization. Ca(2+)-induced formation of one contact was proposed to lead to dimerization followed by Ca(2+)-induced formation of the second contact to bring about polymerization (). To test this mechanism, we compared canine cardiac calsequestrin and four truncation mutants with regard to their folding properties… CONTINUE READING


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