Polymerization and gelation of fibrinogen in D2O.

  title={Polymerization and gelation of fibrinogen in D2O.},
  author={Ulrica Larsson},
  journal={European journal of biochemistry},
  volume={174 1},
The solution properties of fibrinogen and the thrombin-induced activation and gelation of fibrinogen in 95% D2O at pH 7.4 were compared to those in H2O under similar conditions. The initial release rates of fibrinopeptides A and B in D2O were slightly slower than those in H2O. However, the values of the Michaelis-Menten parameters Km and V for the release of the two peptides in D2O and H2O in the presence of 0.5 M NaCl were about the same. From turbidity measurements at 450 nm it is obvious… CONTINUE READING