Polymerization amplified detection for nanoparticle-based biosensing.

  title={Polymerization amplified detection for nanoparticle-based biosensing.},
  author={Adam J Gormley and Robert Chapman and Molly M Stevens},
  journal={Nano letters},
  volume={14 11},
Efficient signal amplification processes are key to the design of sensitive assays for biomolecule detection. Here, we describe a new assay platform that takes advantage of both polymerization reactions and the aggregation of nanoparticles to amplify signal. In our design, a cascade is set up in which radicals generated by either enzymes or metal ions are polymerized to form polymers that can entangle multiple gold nanoparticles (AuNPs) into aggregates, resulting in a visible color change. Less… CONTINUE READING
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