Polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications

  title={Polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications},
  author={Hongsik Yoon and Emma J. Dell and Jessica L. Freyer and Luis M. Campos and Woo Dong Jang},

Soft Supramolecular Nanoparticles by Noncovalent and Host-Guest Interactions.

This review provides an overview of the existing approaches for the formation of supramolecular nanoparticles by various types of noncovalent interactions, with a strong focus on host-guest-mediated assemblies.

Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation.

The promising attributes and unique features of the β-sheet-structured PIC hydrogels described here highlight the potential of harnessing conformational order derived from PIC assembly to create new supramolecular materials.

Synthesis of Robust Surface-Charged Nanoparticles Based on Cyclopropenium Ions

We investigate synthetic strategies of cationic surface-charged nanoparticles using cyclopropenium-based (CP) monomers and block copolyelectrolytes (BCPEs) via surfactant-free emulsion

Clickable Poly(ionic liquids): A Materials Platform for Transfection.

A post-polymerization click reaction is reported that provides facile access to trisaminocyclopropenium (TAC) ion-functionalized macromolecules of various architectures, which are the first class of polyelectrolytes that bear a formal charge on carbon.

100th Anniversary of Macromolecular Science Viewpoint: Attractive Soft Matter: Association Kinetics, Dynamics, and Pathway Complexity in Electrostatically Coassembled Micelles

This Viewpoint focuses on current efforts to study dynamic and out-of-equilibrium processes with greater spatiotemporal detail and highlights different approaches and discusses how they reveal and rationalize similarities and differences in the behavior of mixed micelles prepared under various conditions and from different polymeric building blocks.

Fluorescent Supramolecular Polymeric Materials

In this Review, fluorescent supramolecular polymeric materials are classified depending on the types of main driving forces for supramolescular polymerization, including multiple hydrogen bonding, electrostatic interactions, π-π stacking interactions, metal-coordination, van der Waals interactions and host-guest interactions.

On Complex Coacervate Core Micelles: Structure-Function Perspectives

Recent studies on the functional roles that C3Ms can fulfil in nanomedicine, catalysis, nanoparticle synthesis, and sensing are discussed, focusing on emerging structure–function relations and remaining knowledge gaps.

Electrostatically Driven Assembly of Polyelectrolytes

  • I. Voets
  • Materials Science, Chemistry
  • 2016
Screened electrostatic interactions are commonly employed in colloid and polymer science for stabilization in aqueous solutions to avoid macroscopic phase separation, but these are equally versatile



Supramolecular Assembly of Photofunctional Dendrimers for Biomedical Nano-Devices

Dendrimer photosensitizers, composed of a focal photosensitizing unit surrounded by poly(benzyl ether) dendritic wedges, are introduced for photodynamic therapy (PDT) and show selective accumulation to the ophthalmic neovascular lesion and effective photodynamic effect.

Dendrimer porphyrin-based self-assembled nano-devices for biomedical applications

Dendrimers have attracting great interests in the design of functional materials, and various functional nano-devices, such as DP-loaded polyion complex micelles, ternary complex system for gene delivery, polymer-metal complex micelle, hollow nanocapsules for combination cancer therapy, DP-immobilized surface for diagnostic tools, have been designed through electrostatic interaction with oppositely charged polymeric materials.

Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics.

This work highlights recent contributions toward the design of multilayered assemblies that erode controllably and predictably in physiological environments and permit spatial and temporal control over the administration of macromolecular therapeutics, such as DNA.

Biomaterials and biofunctionality in layered macromolecular assemblies.

Recent research in the field of LbL assembly is summarized and categorized as fabrication, sensing, drug release/delivery, and cell technology. Special emphasis is given to topics such as

Multilayer microcapsules with tailored structures for bio-related applications

The technique for fabrication of hollow multilayer microcapsules is initially established by layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes onto sacrificial colloidal particles

Complex coacervate core micelles.

Hollow polymer shells from biological templates: fabrication and potential applications.

Evidence is provided that the adsorption of lipids on polyelectrolyte layers is a means of producing capsules with controlled permeability properties, and 6-Carboxyfluorescein and Rhodamin 6G were precipitated within the capsules.

Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites

Multilayer films of organic compounds on solid surfaces have been studied for more than 60 years because they allow fabrication of multicomposite molecular assemblies of tailored architecture.

Layer-by-layer assembly of microcapsules and their biomedical applications.

This critical review highlights the advances in assembly of capsules by the LbL technique with focus on tailoring the properties of hydrogen-bonded multilayer capsules by cross-linking, and fabrication of capsules based on covalent bonding and bio-specific interactions.