Polymeric particles for the controlled release of human amylin.


Since its discovery the therapeutic use of the pancreatic hormone amylin has been limited due to its poor water solubility and propensity for amyloid aggregation. We have entrapped the human amylin protein in polymeric nanoparticles, using a single emulsion-solvent evaporation method and investigated its effectiveness in the controlled release of the… (More)
DOI: 10.1016/j.colsurfb.2012.01.021