Polymeric oncolytic adenovirus for cancer gene therapy.

Abstract

Oncolytic adenovirus (Ad) vectors present a promising modality to treat cancer. Many clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies. However, the systemic injection of oncolytic Ad in clinical applications is restricted due to significant liver toxicity and immunogenicity. To overcome these issues, Ad has… (More)
DOI: 10.1016/j.jconrel.2015.10.009

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