Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy.

@article{Aryal2011PolymericNW,
  title={Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy.},
  author={Santosh Aryal and Che-Ming Jack Hu and Liangfang Zhang},
  journal={Molecular pharmaceutics},
  year={2011},
  volume={8 4},
  pages={
          1401-7
        }
}
We report a novel approach for nanoparticle-based combination chemotherapy by concurrently incorporating two different types of drugs into a single polymeric nanoparticle with ratiometric control over the loading of the two drugs. By adapting metal alkoxide chemistry, we synthesize highly hydrophobic drug-poly-L-lactide (drug-PLA) conjugates, of which the polymer has the same chain length while the drug may differ. These drug-polymer conjugates are then encapsulated into lipid-coated polymeric… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

Similar Papers

Loading similar papers…