Polymeric nanoparticles for pulmonary protein and DNA delivery.

  title={Polymeric nanoparticles for pulmonary protein and DNA delivery.},
  author={Jyothi U. Menon and Priya Ravikumar and Amruta Pise and Dipendra Gyawali and Connie C W Hsia and Kytai Truong Nguyen},
  journal={Acta biomaterialia},
  volume={10 6},
Polymeric nanoparticles (NPs) are promising carriers of biological agents to the lung due to advantages including biocompatibility, ease of surface modification, localized action and reduced systemic toxicity. However, there have been no studies extensively characterizing and comparing the behavior of polymeric NPs for pulmonary protein/DNA delivery both in vitro and in vitro. We screened six polymeric NPs: gelatin, chitosan, alginate, poly(lactic-co-glycolic) acid (PLGA), PLGA-chitosan and… CONTINUE READING
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