Polymeric nanoparticles for drug delivery to the central nervous system.

  title={Polymeric nanoparticles for drug delivery to the central nervous system.},
  author={Toral Rohit Patel and Jiangbing Zhou and Joseph M. Piepmeier and W. Mark Saltzman},
  journal={Advanced drug delivery reviews},
  volume={64 7},
The central nervous system (CNS) poses a unique challenge for drug delivery. The blood-brain barrier significantly hinders the passage of systemically delivered therapeutics and the brain extracellular matrix limits the distribution and longevity of locally delivered agents. Polymeric nanoparticles represent a promising solution to these problems. Over the past 40years, substantial research efforts have demonstrated that polymeric nanoparticles can be engineered for effective systemic and local… CONTINUE READING

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