Polymeric nanoparticles conjugate a novel heptapeptide as an epidermal growth factor receptor-active targeting ligand for doxorubicin

Abstract

BACKGROUND This study was performed to develop a functional poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG)-bearing amino-active end group for peptide conjugation. METHODS AND RESULTS PLGA was preactivated following by copolymerization with PEG diamine. The resulting amphiphilic PLGA-PEG copolymer bearing 97.0% of amino end groups had a… (More)
DOI: 10.2147/IJN.S32830

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@inproceedings{Liu2012PolymericNC, title={Polymeric nanoparticles conjugate a novel heptapeptide as an epidermal growth factor receptor-active targeting ligand for doxorubicin}, author={Chia Wen Liu and Wen Jen Lin}, booktitle={International journal of nanomedicine}, year={2012} }