Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines.

@article{Galmarini2008PolymericNC,
  title={Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines.},
  author={Carlos M Galmarini and Galya Warren and Ekta Kohli and Arin D. Zeman and Anton Mitin and Serguei V. Vinogradov},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 10},
  pages={3373-80}
}
The therapeutic efficiency of anticancer nucleoside analogues (NA) strongly depends on their intracellular accumulation and conversion into 5'-triphosphates. Because active NATP cannot be directly administrated due to instability, we present here a strategy of nanoencapsulation of these active drugs for efficient delivery to tumors. Stable lyophilized formulations of 5'-triphosphates of cytarabine (araCTP), gemcitabine (dFdCTP), and floxuridine (FdUTP) encapsulated in biodegradable PEG-cl-PEI… CONTINUE READING