Polymeric nano-encapsulation of 5-fluorouracil enhances anti-cancer activity and ameliorates side effects in solid Ehrlich Carcinoma-bearing mice.

@article{Haggag2018PolymericNO,
  title={Polymeric nano-encapsulation of 5-fluorouracil enhances anti-cancer activity and ameliorates side effects in solid Ehrlich Carcinoma-bearing mice.},
  author={Yusuf A. Haggag and Mohamed Mazloum Osman and Sanaa A. El-Gizawy and Ahmed E. Goda and Maha Mostafa Shamloula and Ahmed Moustafa Faheem and Paul A McCarron},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2018},
  volume={105},
  pages={
          215-224
        }
}
Biodegradable PLGA nanoparticles, loaded with 5-fluorouracil (5FU), were prepared using a double emulsion method and characterised in terms of mean diameter, zeta potential, entrapment efficiency and in vitro release. Poly (vinyl alcohol) was used to modify both internal and external aqueous phases and shown have a significant effect on nanoparticulate size… CONTINUE READING