Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection.

@article{Geest2012PolymericMC,
  title={Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection.},
  author={Bruno G De Geest and Monique A. M. Willart and Hamida Hammad and Bart M. Lambrecht and Charlotte Pollard and Pieter Bogaert and Marina De Filette and Xavier Saelens and Chris Vervaet and Jean Paul Remon and Johan Grooten and Stefaan De Koker},
  journal={ACS nano},
  year={2012},
  volume={6 3},
  pages={2136-49}
}
Recombinant antigens hold high potential to develop vaccines against lethal intracellular pathogens and cancer. However, they are poorly immunogenic and fail to induce potent cellular immunity. In this paper, we demonstrate that polymeric multilayer capsules (PMLC) strongly increase antigen delivery toward professional antigen-presenting cells in vivo… CONTINUE READING