Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney

@inproceedings{Teekampa2017PolymericMF,
  title={Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney},
  author={N. Teekampa and F. Van Dijka and A. Broesdera and M. Eversa and J. Zuidemac and R. Steendamc and E. Postb and J. L. Hillebrandsd and H. W. Frijlinka and K. Poelstrab and L. Beljaarsb and P. Olingaa and W. L. J. Hinrichsa},
  year={2017}
}
  • N. Teekampa, F. Van Dijka, +10 authors W. L. J. Hinrichsa
  • Published 2017
Injectable sustained release drug delivery systems are an attractive alternative for the intravenous delivery of therapeutic proteins. In particular, for chronic diseases such as fibrosis, this approach could improve therapy by reducing the administration frequency while avoiding large variations in plasma levels. In fibrotic tissues the platelet-derived growth factor receptor beta (PDGFβR) is highly upregulated, which provides a target for sitespecific delivery of drugs. Our aim was to develop… CONTINUE READING

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