Polymeric micelles with transient stability : A novel delivery concept

@inproceedings{Nostrum2006PolymericMW,
  title={Polymeric micelles with transient stability : A novel delivery concept},
  author={Cornelus F. van Nostrum and D. Neradovic and Osamu Soga and Wim E Hennink},
  year={2006}
}
The conversion of polymers from a hydrophobic to a more hydrophilic state by a chemical or enzymatic process such as hydrolysis or oxidation, is presented as a way to destabilize self-assembled micelles or vesicles. Amphiphilic block copolymers of polyethylene glycol) (PEG) and a thermosensitive block containing N-isopropylacrylamide (NIPAAm) and 2-hydroxypropylmethacrylamide lactate (HPMAm-lactate) form micelles in aqueous solution above the tunable lower critical solution temperature (LCST… CONTINUE READING