Polymeric micellar pH-sensitive drug delivery system for doxorubicin.

  title={Polymeric micellar pH-sensitive drug delivery system for doxorubicin.},
  author={Martin Hrub{\'y} and Cestm{\'i}r Kon{\'a}k and Karel Ulbrich},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={103 1},
A novel polymeric micellar pH-sensitive system for delivery of doxorubicin (DOX) is described. Polymeric micelles were prepared by self-assembly of amphiphilic diblock copolymers in aqueous solutions. The copolymers consist of a biocompatible hydrophilic poly(ethylene oxide) (PEO) block and a hydrophobic block containing covalently bound anthracycline antibiotic DOX. The starting block copolymers poly(ethylene oxide)-block-poly(allyl glycidyl ether) (PEO-PAGE) with a very narrow molecular… CONTINUE READING


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