Polymeric drugs derived from ibuprofen with improved antiinflammatory profile.

@article{Liso1996PolymericDD,
  title={Polymeric drugs derived from ibuprofen with improved antiinflammatory profile.},
  author={P. A. Liso and Mercedes Vivas Rebuelta and Julio San Rom{\'a}n and A. J. Ibarra Gallardo and Angel Mar{\'i}a Villar},
  journal={Journal of biomedical materials research},
  year={1996},
  volume={32 4},
  pages={
          553-60
        }
}
A new methacrylic monomeric compound bearing Ibuprofen (MIA) and the respective polymethacrylic macromolecular derivative (polyMIA) were evaluated for antiinflammatory properties in order to study their pharmacological activity profile. The macromolecular drug is constituted of Ibuprofen residues linked covalently to a polymethacrylic support, as a side substituent of the repeating unit, by means of a spacer group (p-aminophenoxy) that, in addition, is the most representative metabolite of… CONTINUE READING
BETA