Polymeric delivery of therapeutic RAE-1 plasmid to the pancreatic islets for the prevention of type 1 diabetes.

@article{Joo2012PolymericDO,
  title={Polymeric delivery of therapeutic RAE-1 plasmid to the pancreatic islets for the prevention of type 1 diabetes.},
  author={Wan Seok Joo and Ji Hoon Jeong and Kihoon Nam and Katherine S. Blevins and Mohamed E. Salama and Sung Wan Kim},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={162 3},
  pages={
          606-11
        }
}
The activating receptor NKG2D plays an important role in the development of type-1 diabetes. Exploiting a natural phenomenon observed in tumors, plasmid DNA encoding for a soluble ligand to NKG2D (sRAE-1γ) was isolated and engineered into a plasmid expression system. A polymeric gene delivery system was developed to deliver the soluble RAE-1 plasmid to the pancreatic islets. The bioreducible cationic polymer poly(cystamine bisacrylamide-diamino hexane) (p(CBA-DAH)) was modified with poly… CONTINUE READING
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