Polymerase chain reaction for detection of residual leukaemia.

@article{Morgan1989PolymeraseCR,
  title={Polymerase chain reaction for detection of residual leukaemia.},
  author={Gareth J Morgan and Tim Hughes and J. W. Janssen and J B Gow and Alex Guo and John M. Goldman and Leanne M Wiedemann and Claus Rainer Bartram},
  journal={Lancet},
  year={1989},
  volume={1 8644},
  pages={928-9}
}
The occasional finding of cells positive for the Philadelphia (Ph) chromosome months or years after bone-marrow transplantation for chronic myeloid leukaemia raises the possibility that the Ph-positive clone may never be eradicated. The polymerase chain reaction with probes able to detect the transcript of the bcr/abl hybrid gene at very low levels was used to study marrow cells from seven patients in continuing haematological and cytogenetic remission 5-7 years after allogeneic bone-marrow… CONTINUE READING