Polymerase chain reaction-based detection of clonality as a non-morphologic diagnostic tool for fine-needle aspiration of the breast.

@article{Magda1998PolymeraseCR,
  title={Polymerase chain reaction-based detection of clonality as a non-morphologic diagnostic tool for fine-needle aspiration of the breast.},
  author={J L Magda and B A Minger and David L. Rimm},
  journal={Cancer},
  year={1998},
  volume={84 4},
  pages={262-7}
}
BACKGROUND Fine-needle aspiration (FNA) of breast specimens can be difficult and between 10-25% of the lesions ultimately are classified as "atypical," even by the most experienced cytopathologist. The goal of this study was to identify a molecular mechanism that reliably distinguishes benign and malignant (or pre-malignant) lesions and that could be used as an adjunct in these morphologically ambiguous cases. METHODS Because all malignancies represent clonal proliferations, assessment of… CONTINUE READING