Polymerase chain reaction aids in the diagnosis of an unusual case of Aspergillus niger endocarditis in a patient with acute myeloid leukaemia.

@article{McCracken2003PolymeraseCR,
  title={Polymerase chain reaction aids in the diagnosis of an unusual case of Aspergillus niger endocarditis in a patient with acute myeloid leukaemia.},
  author={Dean McCracken and Rosemary Barnes and Clare B. Poynton and Patricia L White and Nilgun Isik and David Cook},
  journal={The Journal of infection},
  year={2003},
  volume={47 4},
  pages={344-7}
}
Endocarditis secondary to Aspergillus niger has not been described in a leukaemic patient. We describe a case of A. niger endocarditis in a patient with acute myeloid leukaemia and refractory fever. The microbiological cause of his endocarditis was initially misdiagnosed because he fulfilled the Duke criteria for enterococcal endocarditis. A polymerase chain reaction test utilizing pan-fungal primers detected a product from an Aspergillus sp. The DNA was subsequently sequenced and was found to… CONTINUE READING