Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs.

@article{Woodfield2005PolymerSF,
  title={Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs.},
  author={Tim B F Woodfield and Clemens A van Blitterswijk and JR de Wijn and Trevor J. Sims and Anthony P Hollander and J E - IsoTis N. V. Riesle},
  journal={Tissue engineering},
  year={2005},
  volume={11 9-10},
  pages={1297-311}
}
The zonal organization of cells and extracellular matrix (ECM) constituents within articular cartilage is important for its biomechanical function in diarthroidal joints. Tissue-engineering strategies adopting porous three-dimensional (3D) scaffolds offer significant promise for the repair of articular cartilage defects, yet few approaches have accounted for the zonal structural organization as in native articular cartilage. In this study, the ability of anisotropic pore architectures to… CONTINUE READING