Polymer particle erosion controlling drug release. I. Factors influencing drug release and characterization of the release mechanism.

@article{Zuleger2001PolymerPE,
  title={Polymer particle erosion controlling drug release. I. Factors influencing drug release and characterization of the release mechanism.},
  author={Susanne Zuleger and Bernhard Christian Lippold},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={217 1-2},
  pages={139-52}
}
The present study deals with controlled drug delivery from hydrocolloid tablets by polymer particle erosion. The influence of excipients and formulation factors on the dissolution behaviour of the methyl hydroxyethyl cellulose (MHEC)-tablets is investigated. Linear drug release with low susceptibility to hydrodynamic stress is obtained. The use of drugs with higher solubility leads to a slight acceleration of the release due to the contribution of diffusion to the release process. Higher drug… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…