Polymer networks with grafted cell adhesion peptides for highly biospecific cell adhesive substrates.

@article{Drumheller1994PolymerNW,
  title={Polymer networks with grafted cell adhesion peptides for highly biospecific cell adhesive substrates.},
  author={Paul D. Drumheller and Jeffrey A Hubbell},
  journal={Analytical biochemistry},
  year={1994},
  volume={222 2},
  pages={
          380-8
        }
}
Polymer networks of poly(ethylene glycol) (PEG) in densely cross-linked matrices of acrylic acid (AA) and trimethylolpropane triacrylate were synthesized as biospecific cell adhesive substrates. Networks grafted with synthetic adhesion peptides produced substrates to investigate long-term, receptor-mediated cell/surface interactions, without nonspecific protein adsorption producing spurious adhesion signals. PEG rendered the networks very resistant to cell adhesion in vitro, and AA provided… CONTINUE READING

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