Polymer nanoparticles containing 2,4,6-triiodophenol: a potential contrast medium for medical imaging.

Abstract

Contrast agents have been utilized for x-ray imaging to visualize blood vessels. Triiodobenzene derivatives are known contrast agents yet have not been formulated in a nanoparticle form for the purpose of enhancing the contrast of cancer tissues. In this study, experiments to encapsulate 2,4,6-triiodophenol in a polymer matrix were designed. Spherical NPs made of PLA, PLGA, PLA-TPGS, PLGA-TPGS and TPGS-FOL, were synthesized and characterized. Using the oil-in-water single-emulsion technique, the effect of several experimental parameters such as sonication power, ratio of 2,4,6-triiodophenol/polymer, type and concentration of emulsifier, and polymer type has been studied. A good morphology of polymer NPs with entrapped 2,4,6-triiodophenol was successfully obtained however the encapsulated iodine was in the range of 5 to 26%.

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Cite this paper

@article{ElBatta2014PolymerNC, title={Polymer nanoparticles containing 2,4,6-triiodophenol: a potential contrast medium for medical imaging.}, author={Amer El-Batta and Hasan A Al-Muallem and Mohammed Nasiruzzaman Shaikh and N. Maalej}, journal={Acta chimica Slovenica}, year={2014}, volume={61 2}, pages={414-9} }