Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicing.

@article{Cheng2012PolymerND,
  title={Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicing.},
  author={Christopher J. Cheng and W. Mark Saltzman},
  journal={Molecular pharmaceutics},
  year={2012},
  volume={9 5},
  pages={1481-8}
}
The crux of current RNA-based therapeutics relies on association of synthetic nucleic acids with cellular RNA targets. Antisense oligonucleotide binding to mature microRNA and splicing junctions on pre-mRNA represent methods of gene therapy that respectively inhibit microRNA-mediated gene regulation and induce alternative splicing. We have developed biodegradable polymer nanoparticles, which are coated with cell-penetrating peptides, that can effectively deliver chemically modified… CONTINUE READING
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