Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel.

Abstract

Osmotic stress can be used to estimate the internal volume change during the opening and closing of a voltage gated ionic channel. Mitochondrial voltage-dependent anion channels, from rat liver and from Neurospora, reconstituted into planar lipid bilayers show a change of 2 to 4 X 10(4) A3 in internal volume, a large change inconsistent with a blocking or local gating model but supporting models with major closure of the channel space.

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@article{Zimmerberg1986PolymerIV, title={Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel.}, author={Joshua Zimmerberg and V. Adrian Parsegian}, journal={Nature}, year={1986}, volume={323 6083}, pages={36-9} }