Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation.

  title={Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation.},
  author={Paolo Marizza and Stephan Sylvest Keller and Anette M{\"u}llertz and Anja Boisen},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
In the last years a large variety of drug delivery systems have been developed to improve bioavailability of therapeutics in oral administration. An increasing interest has arisen in reservoir-based microdevices designed for active ingredients like water insoluble compounds and fragile biomolecules. Such microdevices are designed to protect the active ingredient against degradation and deactivation, and to allow cytoadhesion and unidirectional drug release. There are few works which optimize… CONTINUE READING
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